Aging is not just about accumulating years; it is the sum of hundreds of decisions our cells make every day. Modern science has managed to describe this process through 12 hallmarks of aging, a kind of "map" that explains how and why our cells lose efficiency over time.
At iove, we believe that understanding this map is essential to intelligently support biology. Moreover, we know that many of these hallmarks share common pathways that can be modulated from their origin.
And among these origins, one stands out: sirtuins, especially the axes regulated by SIRT1 and SIRT3.
The 12 Hallmarks of Aging: An Integrative Vision
Although scientific literature sometimes explains them separately, the 12 hallmarks function as an ecosystem: they influence and feed back into each other, and when one is altered, the others tend to become unbalanced. This original article describes these 12 key processes, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and gut dysbiosis.
Together, they paint a broad picture of what it means to age at a cellular level.
But the most interesting part for iove is not just understanding them... but identifying which control points can simultaneously influence several of them.
And this is where sirtuins come in.
Sirtuins: the transversal regulators
Sirtuins form a family of proteins (SIRT1–SIRT7) involved in processes that span the 12 hallmarks: from metabolism to DNA repair, nutrient management, and mitochondrial communication. When they decrease—which is common with age—essential pathways for cell health become unbalanced.
The most relevant aspect is not just their individual function, but their orchestrating capacity:
when activated, they can simultaneously modulate several hallmarks of aging.
How Pteroyouth® intervenes in this map
Pteroyouth® is a patented combination of polyphenols, at the core of iove. Its value lies not only in its natural origin but in its surprising synergy, difficult to reproduce from its components separately.
What internal science has observed about Pteroyouth®:
✔ Activation of SIRT1 and SIRT3
Fundamental axes of longevity, repair, and metabolic regulation.
✔ Boost of the Nrf2 antioxidant pathway
Key to protecting against oxidative stress associated with several of the 12 hallmarks.
✔ Improvement of autophagy and mitophagy
Processes intimately related to proteostasis, mitochondrial quality, and damage accumulation.
✔ Support for mitochondrial function
Mitochondria are protagonists in at least four hallmarks of aging; improving them has cascading effects.
✔ Impact on pathways that influence several hallmarks simultaneously
It does not act as an isolated agent but as a modulator of the biological network.
Pteroyouth® does not target a specific "hallmark" but rather the systems that allow the cell to maintain its global balance. This makes it an ally aligned with the iove philosophy: caring for the origin to transform the outcome.
An approach for those who want to understand aging, not fight it
The purpose of iove is not to stop time but to accompany the processes that define vitality. For us, aging well means aging with biological coherence, maintaining our cells' adaptive capacity.
That's why we work with pathways such as:
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Sirtuins
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Nrf2
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Autophagy and mitophagy
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Repair mechanisms
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Energy homeostasis
And that's why we chose a polyphenolic combination like Pteroyouth®, capable of acting where it all really begins: in the way your biology organizes its own balance.
A new way to read the 12 signs
This article is not intended to offer simplistic solutions to each sign, but to show an idea that defines iove:
Aging is not a list of isolated problems.
It is a complex system that can be rebalanced from common control points.
Sirtuins are one such point.
Pteroyouth® is our way of accompanying them.
iove is the way to bring that science to real life.